A recent study suggests that individuals who come off new GLP-1 drugs like Wegovy and Mounjaro can put back on reduced body mass much more quickly than those who halt traditional lifestyle programs.
Findings released in a major health publication shows that while overweight people can lose about a fifth of their total mass while on the medication, the mass returns at an estimated rate of 0.8 kg per month once they quit.
"Users using such medications must be aware of the danger of rapid rebound weight gain when the therapy is stopped," stated researcher Dr. Susan Jebb.
Such speed of regain implies a reversion to starting weight within about a year and a half.
Comparing Therapies
The analysis, which reviewed 37 of studies involving thousands of participants, contrasted the results of GLP-1 agonists with older methods.
The team emphasize that people who shed pounds through lifestyle changes alone generally see a slower weight regain—approximately 0.1 kg a month—post-intervention.
Explaining the Quick Rebound
Nutrition scientists believe the mechanism of the drugs explains the accelerated regain.
GLP-1 drugs copy a natural hormone called glucagon-like peptide-1, which helps regulate appetite.
"Artificially providing the hormone levels far above than the body's typical production might result in the system to generate a reduced amount of its own natural hormone, and could reduce responsiveness to its effects," noted Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this hormone supplement means appetite is no longer kept in check, making overeating a significant risk."
An Ongoing Issue?
Health authorities advise the jabs for people with weight-linked health risks, accompanied by prescribed lifestyle changes.
A number of clinicians argue that, considering the likelihood of relapse, the treatment should be considered life-long.
This view is supported by drug manufacturers, who note that the findings "underscore the long-term nature of obesity," similar to managing diseases like hypertension.
User Experiences
Users who have stopped the medication report a powerful return of cravings.
"I experienced something activating and you become ravenous," recalled a patient.
The struggle is worsened if individuals have not established sustainable dietary or behavioural changes during therapy.
Widespread Use
Recent estimates indicate that a significant number of people in the UK have used these injections in the last 12 months, with desire being substantial.
- Use is higher among females compared to men.
- The middle-aged age group shows the highest usage rates.
- Many obtain the medications through private healthcare rather than public health services.
Ultimately, researchers stress that while the jabs are effective agents for weight loss, they are not a magic cure and lasting health benefits hinges on combined lifestyle support.
